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While the function of sweating is to prevent overheating, those affected sweat even when the body does not need cooling. Existing therapies for excessive underarm sweating, also called axillary hyperhidrosis, offer limited effectiveness and can be expensive. The first line of defense are antiperspirants. Next, patients can try costlier alternatives such as botox injections, a device called miraDry that delivers electromagnetic energy to decompose sweat glands, or laser therapy to destroy them. Sufferers can also opt for localized surgery, like liposuction, to remove or injure sweat glands. Oral medicines can be used to systemically limit sweating. For instance, a class of drugs called anticholinergics are commonly used off-label for this purpose, but they are linked with the risk of dementia. Based on the most recent estimates, about 7.8 million Americans have some form of excessive sweating including palms, feet, underarms or head, and about half of this population suffer from the underarm form, said Dermira spokeswoman Erica Jefferson, in an interview ahead of the data readout. The Menlo Park, California-based company's shares were up 3 percent at $33.00 in extended trading on Wednesday.